Guanylyl cyclase C as a biomarker in colorectal cancer
نویسندگان
چکیده
منابع مشابه
Guanylyl cyclase C messenger RNA is a biomarker for recurrent stage II colorectal cancer.
BACKGROUND Patients with stage II colorectal cancer and no histologic evidence of lymph node invasion develop recurrent disease, presumably because of undetected micrometastases. Guanylyl cyclase C is expressed by intestinal and colorectal cancer cells but not by extraintestinal tissues or tumors. OBJECTIVE To examine the expression of guanylyl cyclase C messenger RNA (mRNA) in lymph nodes of...
متن کاملGuanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer.
Obesity has emerged as a principal cause of mortality worldwide, reflecting comorbidities including cancer risk, particularly in colorectum. Although this relationship is established epidemiologically, molecular mechanisms linking colorectal cancer and obesity continue to be refined. Guanylyl cyclase C (GUCY2C), a membrane-bound guanylyl cyclase expressed in intestinal epithelial cells, binds t...
متن کاملGuanylyl cyclase C signaling axis and colon cancer prevention
Colorectal cancer (CRC) is a major cause of cancer-related mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, and patient survival has seen little benefit. Consequently, additional advances in CRC treatments remain important, with an emphasis on preventative measures. Guanylyl cyclase C (...
متن کاملA Pilot Study of CK19, CK20 and GCC mRNA in the Peripheral Blood as a Colorectal Cancer Biomarker Panel
Colorectal cancer remains one of the major cancer- related deaths despite progress in the treatment during past decades. Detection of disease at earlier stages reduces its mortality. The aim of current study was to investigate expression of Cytokeratin 19 (CK19), Cytokeratin 20 (CK20) and Guanylyl Cyclase C (GCC) mRNA in peripheral blood of non- metastatic colorectal cancer patients which may r...
متن کاملGlycosylation of human receptor guanylyl cyclase C
Background Post translational modifications regulate several signalling pathways and glycosylation is emerging as a key player in this regulatory process. Glycosylation of cell surface receptors modulate the downstream signalling pathway and when altered causes a change in the normal physiology of the cell [1]. Guanylyl cyclase C (GC-C) belongs to a group of membrane bound receptors that produc...
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ژورنال
عنوان ژورنال: Biomarkers in Medicine
سال: 2013
ISSN: 1752-0363,1752-0371
DOI: 10.2217/bmm.12.90